Publicación

Tipo de publicación: Artículos científicos (Publicados en revistas de divulgación o científicas)

Título del artículo: Association of IL-6 rs1800795 polymorphism with type 2 diabetes and related clinical traits

Registrado por: Revista Médica de la Universidad de Costa Rica

Año de publicación: 2024

Resumen: Interleukin-6 (IL-6) is an inflammatory cytokine which could favor type 2 diabetes development (T2D) by negatively regulating insulin signaling. IL-6 rs1800795 polymorphism has been associated with T2D in several populations and may be involved in its development. The aim was to determine whether the IL-6 rs1800795 (G>C) polymorphism is associated with T2D and related clinical traits. A case control study was conducted in individuals from a population of Mérida, Yucatán, Mexico, being 198 T2D cases and 162 controls. Anthropometric and biochemical parameters were taken and the rs1800795 polymorphism was genotyped by real-time PCR. Obese men carrying the GC genotype (p=0.036, OR=0.199) and C allele (0.046, OR=0.240) had reduced risk for T2D. Higher levels of systolic blood pressure were observed in diabetic individuals carrying the GG genotype (141.750±25.240) compared to GC carriers (128.769±20.713). A similar result was obtained in an analysis regardless of the diabetes presence. In conclusion rs1800795 polymorphism could be a protective factor for T2D in obese male individuals. The GG genotype was associated with higher blood pressure levels regardless of T2D presence.

Editorial:

Número de páginas:

Autor(es): Nicolas Fragoso-Bargas, Nina Valadez González, Lorena Ruiz García, Ligia Vera-Gamboa, Víctor Manuel Martínez Aguilar, Yumi Elena Nakazawa Ueji, Guillermo Valencia Pacheco

Campo:

Disciplina:

Subdisciplina:

Número de registro: DOI:10.15517/rmucr.v18i1.56934