Publicación

Tipo de publicación: Artículos científicos (Publicados en revistas de divulgación o científicas)

Título del artículo: Genomic Evolution Strategy in SARS-CoV-2 Lineage B: Coevolution of Cis Elements

Registrado por: Current Issues in Molecular Biology

Año de publicación: 2024

Resumen: In the SARS-CoV-2 lineage, RNA elements essential for its viral life cycle, including genome replication and gene expression, have been identi?ed. Still, the precise structures and Functions of these RNA regions in coronaviruses remain poorly understood. This lack of Knowledge points out the need for further research to better understand these crucial aspects of viral biology and, in time, prepare for future outbreaks. In this research, the in silico analysis of the cis RNA structures that act in the alpha-beta-gamma-, and deltacoronavirus genera has provided a detailed view of the presence and adaptation of the structures of these elements in coronaviruses. The results emphasize the importance of these cis elements in viral biology and their variability between di?erent viral variants. Some coronavirus variants in some groups, depending on the cis element (stem-loop1 and -2; pseudoknot stem-loop1 and -2, and s2m), exhibited functional adaptation. Ad-ditionally, the conformation ?exibility of the s2m element in the SARS variants was determined, suggesting a coevolution of this element in this viral group. The variability in secondary structures suggests genomic adaptations that may be related to replication processes, genetic regulation, as well as the speci?c pathogenicity of each variant. The results suggest that RNA structures in coronaviruses can adapt and evolve toward di?erent viral variants, which has important implications for viral adaptation, pathogenicity, and future therapeutic strategies.

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Autor(es): Yahaira de J. Tamayo-Ordóñez ,Ninfa M. Rosas-García, Francisco A. Tamayo-Ordoñez, Benjamín A. Ayil-Gutiérrez, Juan M. Bello-López,Gerardo de J. Sosa-Santillán , Erika Acosta-Cruz, Francisco Anguebes-Franseschi, Siprian Damas-Damas , Angel V. Domínguez-May , Atl Victor Córdova-Quiroz and María Concepción Tamayo-Ordóñez

Campo: Ciencias biológicas

Disciplina: Biotecnología

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